Terpene Science

Cannabinoids, Terpenes and the Entourage Effect


Cannabinoids are a group of closely related compounds that include cannabinol and the active constituents of cannabis.   The most famous being THC, formally ∆9-Tetrahydrocannabinol, the compound responsible for strong psychoactive properties of cannabis.  Cannabidiol, also known as CBD, is a powerful cannabinoid used to treat a variety of physical and mental conditions.  Cannabinoids act like the compounds humans naturally produce called endocannabinoids.  Other major cannabinoids include Cannabinol (CBN), Cannabigerol (CBG), Cannabichromene (CBC), ∆1-Tetrahydrocannabinolic Acid (THC-A) and Cannabidiolic Acid (CBD-A).  Read more about Cannabinioids…


Terpenes are a large and diverse class of organic compounds, produced by a variety of plants, including cannabis.  Cannabis contains hundreds of terpenes.   Terpenes are responsible for the smell and taste of cannabis as well as many of the beneficial properties.   Each cannabis strain has a profile comprised of the concentrations and relative proportions of each terpene.   For example, Indica is rich in the terpene Myrcene, known to induce relaxation and may cause drowsiness.   While Sativa is high in limonene and other terpenes related to alertness and energy, as well as lemon and citrus flavor.  Terpenes work in combination with cannabinoids, including THC and CBD, to enhance these effects.  The synergy of terpenes and cannabinoids is the Entourage Effect.    Read more about Terpenes…

What is The Entourage Effect

The synergy of terpenes and cannabinoids is the Entourage Effect.  The combination is greater than the sum of the individual compounds.  Ironically, isolating THC diminishes the benefits of cannabis.  Pioneering Israeli researchers Shimon Ben-Shabat and Raphael Mechoulam first articulated the synergy of cannabinoids and terpenes in 1998.  Working together, the compounds in cannabis complement one another like the human endocannabinoid system.  The entourage effect is responsible for many of the therapeutic benefits in cannabis and in Doctor Terpene formulations.  

Why Microdose?

Patient response to most medications is a bell shaped curve.  Too little is ineffective, and too much results in diminishing efficacy and potential negative effects.  Each individual responds differently as well.  Low dosage and microdosing allow the patient to titrate the desired effect.  For many patients, less is more.   Read more about microdosing. 

Why Doctor Terpene?

Today, individual strains and hybrids have been cultivated to offer combinations of terpenes and cannabinoids with desirable effects.  But there is no perfect strain for Sleep, nor for Energy, Relaxation, Inflammation, Diet or Pain.  To optimize medicinal and psychoactive benefits requires specific formulations – Terpene Science.  Doctor Terpene has developed precise formulations for the treatment of specific conditions.   How is this possible?  After the cannabis has been distilled into oil, Doctor Terpene re-introduces the natural terpenes to the optimum levels for the desired effect. The result – The Perfect Strain.

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